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. 2012 Dec 17;6:429–464. doi: 10.2147/BTT.S36707

Figure 2.

Figure 2

Network diagram for ACR20/50/70 outcomes for bDMARD combination therapies.

Notes: 1, Abe 2006; 2, Chen 2009; 3, Combe 2006; 4, Durez 2004; 5, Edwards 2004; 6, Emery 2010 (SERENE); 7, Genovese 2004; 8, Genovese 2008 (TOWARD); 9, Huang 2009; 10, Kameda 2010 (JESMR); 11, Kay 2008; 12, Keystone 2004 (DE019); 13, Keystone 2008 (RAPID 1); 14, Keystone 2009 (GO-FORWARD); 15, Kim 2007; 16, Kremer 2003; 17, Kremer 2006 (AIM); 18, Kremer 2010; 19, Lan 2004; 20, Maini 1999 (ATTRACT); 21, Maini 2006 (CHARISMA); 22, Schiff 2008 (ATTEST); 23, Smolen 2008 (OPTION); 24, Smolen 2009a (RAPID 2); 25, van Riel 2006 (ADORE); 26, Weinblatt 1999; 27, Weinblatt 2003 (ARMADA); 28, Westhovens 2006b (START); 29, Zhang 2006. DMARD 25 arms, 3039 patients; abatacept 10 mg/kg/4 weeks + DMARD 3 arms, 704 patients; adalimumab 40 mg/2 weeks + DMARD 5 arms, 495 patients; certolizumab pegol 200 mg/2 weeks + DMARD 2 arms, 639 patients; etanercept 2 × 25 mg/week + DMARD 6 arms, 500 patients; golimumab 50 mg/4 weeks + DMARD 2 arms, 124 patients; infliximab 3 mg/kg/8 weeks + DMARD 6 arms, 760 patients; rituximab 2 × 1000 mg + DMARD 2 arms, 212 patients; tocilizumab 8 mg/kg/4 weeks + DMARD 3 arms, 1058 patients.