Table S7.

Direct and indirect meta-analysis of ACR50 on Tocilizumab 4 mg/kg/4 weeks—Tocilizumab 8 mg/kg/4 weeks loop

Meta-analysis of ACR50	Comparator	OR	Lower 95% CI	Upper 95% CI	P value
Direct
Tocilizumab 4 mg/kg/4 weeks	MTX	0.962	0.407	2.271	0.929
Tocilizumab 4 mg/kg/4 weeks	Placebo	18.2	2.296	144.262	0.006
Tocilizumab 8 mg/kg/4 weeks	MTX	3.663	0.784	17.123	0.099
Tocilizumab 8 mg/kg/4 weeks	Placebo	34.667	4.459	269.54	0.001
Indirect via MTX
Tocilizumab 8 mg/kg/4 weeks	Tocilizumab 4 mg/kg/4 weeks	3.808	0.652	22.251	0.138
Indirect via placebo
Tocilizumab 8 mg/kg/4 weeks	Tocilizumab 4 mg/kg/4 weeks	1.905	0.103	35.109	0.665
Inconsistency on loop		1.999	0.066	60.328	0.690

Abbreviations: OR, odds ratio; CI, confidence interval; MTX, methotrexate.