Table S8.

Direct and indirect meta-analysis of ACR20 on Tocilizumab 4 mg/kg/4 weeks—Tocilizumab 8 mg/kg/4 weeks loop

Meta-analysis of ACR20	Comparator	OR	Lower 95% CI	Upper 95% CI	P value
Direct
Tocilizumab 4 mg/kg/4 weeks	MTX	2.279	1.034	5.02	0.041
Tocilizumab 4 mg/kg/4 weeks	Placebo	10.558	3.859	28.885	0.000
Tocilizumab 8 mg/kg/4 weeks	MTX	5.417	1.195	24.546	0.028
Tocilizumab 8 mg/kg/4 weeks	Placebo	28.069	9.689	81.318	0.000
Indirect via DMARD
Tocilizumab 8 mg/kg/4 weeks	Tocilizumab 4 mg/kg/4 weeks	2.377	0.432	13.084	0.320
Indirect via placebo
Tocilizumab 8 mg/kg/4 weeks	Tocilizumab 4 mg/kg/4 weeks	2.659	0.615	11.498	0.191
Inconsistency on loop		0.894	0.094	8.465	0.922

Abbreviations: OR, odds ratio; CI, confidence interval; MTX, methotrexate; DMARD, disease modifying anti-rheumatic drug.