Table S9.

Direct and indirect meta-analysis of ACR70 on Tocilizumab 4 mg/kg/4 weeks—Tocilizumab 8 mg/kg/4 weeks loop

Meta-analysis of ACR70	Comparator	OR	Lower 95% CI	Upper 95% CI	P value
Direct
Tocilizumab 4 mg/kg/4 weeks	MTX	0.281	0.068	1.161	0.079
Tocilizumab 4 mg/kg/4 weeks	Placebo	40.932	2.328	719.842	0.011
Tocilizumab 8 mg/kg/4 weeks	MTX	4.668	0.304	71.629	0.269
Tocilizumab 8 mg/kg/4 weeks	Placebo	40.714	2.276	728.176	0.012
Indirect via DMARD
Tocilizumab 8 mg/kg/4 weeks	Tocilizumab 4 mg/kg/4 weeks	16.612	0.765	360.725	0.074
Indirect via placebo
Tocilizumab 8 mg/kg/4 weeks	Tocilizumab 4 mg/kg/4 weeks	0.995	0.017	58.049	0.998
Inconsistency on loop		16.701	0.102	2739.729	0.279

Abbreviations: OR, odds ratio; CI, confidence interval; MTX, methotrexate; DMARD, disease modifying anti-rheumatic drug.