TABLE 4 .
Overrepresented Immune-Related GO Terms Correlating With TCDD and PCB Exposure
| TCDD | PCB77 | PCB126 | PCB153 | PCB169 | |
|---|---|---|---|---|---|
| p value | |||||
| Significant GO processes in males | |||||
| Regulation of I-kappaB kinase/NF-kappaB cascade | 2,500E−03 | ||||
| Positive regulation of I-kappaB kinase/NF-kappaB cascade | 4,574E−03 | ||||
| Regulation of defense response | 9,764E−03 | ||||
| Viral infectious cycle | 1,271E−04 | ||||
| Negative regulation of multiorganism process | 5,379E−03 | 7,308E−03 | |||
| Protein folding | 7,361E−04 | ||||
| Regulation of lymphocyte activation | 6,633E−03 | 8,900E−03 | |||
| Regulation of cytokine production | 8,061E−03 | 4,550E−03 | 7,981E−03 | ||
| Antigen processing and presentation of peptide antigen via major histocompatibility complex class I | 1,925E−04 | 9,157E−03 | 1,682E−04 | ||
| Histone acetylationa | 4,331E−03 | 8,065E−03 | |||
| Posttranscriptional regulation of gene expression | 7,099E−04 | 9,479E−03 | |||
| Significant GO processes in females | |||||
| Regulation of I-kappaB kinase/NF-kappaB cascade | 6,102E−03 | 2,204E−03 | |||
| Positive regulation of I-kappaB kinase/NF-kappaB cascade | 4,029E−03 | 1,251E−03 | |||
| Regulation of defense response | 7,308E−03 | ||||
| Viral infectious cycle | 7,154E−03 | ||||
| Negative regulation of multiorganism process | 4,833E−03 | ||||
| Protein folding | 1,641E−03 | ||||
| Regulation of T-cell proliferation | 5,436E−03 | 3,710E−03 | |||
| Positive regulation of cytokine-mediated signaling pathway | 1,190E−03 | 5,670E−04 | 2,846E−03 | ||
| Activation of caspase activity by cytochrome c | 6,642E−03 | ||||
| Glial cell apoptosis | 3,947E−03 | 6,037E−03 | |||
Note. For the complete list, refer to Supplementary table 1.
aSeveral histone acetylation GO terms were overrepresented; for complete list, refer to Supplementary table 1.