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miRNAs endonucleic cleavage. Upon miRNAs-directed association of the RNA-induced silencing complex (RISC) with mRNAs, the intrinsic enzymatic protein Argonaute 2 can induce endonucleic cleavage. This is possible as a result of the RNase H activity of the PIWI domain of Argonaute 2. The mRNAs fragments then undergo exonuclease degradation.
