Table 2.
Age- and multivariable-adjusteda HRs (95% CI) for breast cancer according to any migraine history (n=39,696)
| No migraine (n=32,378) | Any migraine (n=7,318) | ||||
|---|---|---|---|---|---|
| Age-adjusted | Multivariable-adjusted | ||||
| No of cases | HR (95% CI) | No of cases | HR (95% CI) | HR (95% CI) | |
| Any breast cancer (n=2,278) | 1,841 | 1.00 | 437 | 1.08 (0.97, 1.20) | 1.10 (0.99, 1.22) |
| In situ breast cancer (n=432) | 351 | 1.00 | 81 | 1.03 (0.81, 1.32) | 1.06 (0.83, 1.35) |
| Invasive breast cancer (n=1,846) | 1,490 | 1.00 | 356 | 1.09 (0.97, 1.22) | 1.11 (0.99, 1.25) |
| ER/PR status | |||||
| ER+/PR+ (n=1,237) | 1,018 | 1.00 | 219 | 0.99 (0.85, 1.14) | 1.01 (0.87, 1.17) |
| ER+/PR− (n=213) | 170 | 1.00 | 43 | 1.17 (0.84, 1.64) | 1.19 (0.85, 1.66) |
| ER−/PR+ (n=28) | 22 | 1.00 | 6 | 1.17 (0.47, 2.90) | 1.17 (0.47, 2.91) |
| ER−/PR− (n=263) | 203 | 1.00 | 60 | 1.30 (0.97, 1.73) | 1.28 (0.96, 1.71) |
| Histology | |||||
| Ductal (n=1,356) | 1,090 | 1.00 | 266 | 1.11 (0.97, 1.26) | 1.12 (0.98, 1.29) |
| Lobular (n=206) | 173 | 1.00 | 33 | 0.90 (0.62, 1.31) | 0.91 (0.63, 1.33) |
| Ductal and lobular (n=148) | 122 | 1.00 | 26 | 0.98 (0.64, 1.50) | 1.01 (0.66, 1.55) |
a
Multivariable models were adjusted for age, BMI, alcohol consumption, smoking status, postmenopausal status, age at menarche, age at menopause, postmenopausal hormone use, hormone replacement therapy use, number of pregnancies, age at first pregnancy, family history of breast cancer, history of benign breast disease