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. Author manuscript; available in PMC: 2014 Feb 28.
Published in final edited form as: Oncogene. 2012 Sep 17;32(35):4078–4085. doi: 10.1038/onc.2012.421

Figure 3.

Figure 3

A subset of NestinCreBaxfl/flBak−/− brain tumors exhibit high grade features. An exemplary aggressive brain tumor was associated with gross head deformity (A) and pronounced compression with midline shift (B and C). Arrow, central sulcus (D–G) H&E-stained sections revealed malignant-appearing cells streaming from the SVZ, with a fasicular growth pattern, perivascular cuffing, mitotic cells, and satellitosis. (H–K) Tumor cells were NeuN- (H), Sox2- (I), and Olig2-positive (J), and exhibited a high Ki-67 proliferation index (K).