Skip to main content
. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Immunol. 2012 Nov 30;190(1):447–457. doi: 10.4049/jimmunol.1201641

FIGURE 5. Tumor-presensitized donor B10.BR CD8+Vβ13+ T cells elicit a significant GVL effect with minimal GVHD.

FIGURE 5

CBA mice were exposed to lethal irradiation (11 Gy, split dose) and transplanted with ATBM cells (2×106) alone or along with either CD8+ T cells (1×107) or CD8+Vβ13+ T cells (1x, 8.34×105 or 3x, 2.5×106) from MMC6 presensitized or naïve donor B10.BR mice. Transplanted mice were challenged with MMC6 tumor cells (5×103) on d 1 post-BMT. Experiments were repeated twice, each with 4-5 mice per group. Statistical significance between survival curves was determined using the non-parametric Wilcoxon test. ATBM + MMC6 versus ATBM + MMC6 + CD8+Vβ13+ T cells (1x presensitized), p <0.01; ATBM + CD8+ T cells + MMC6 versus ATBM + MMC6 + CD8+Vβ13+ T cells (1x presensitized), p < 0.05; ATBM + MMC6 + CD8+Vβ13+ T cells (1x), versus ATBM + MMC6 + CD8+Vβ13+ T cells (1x presensitized), p = 0.03.