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. Author manuscript; available in PMC: 2014 Jan 25.
Published in final edited form as: Mol Pharm. 2012 Jul 25;9(8):2187–2196. doi: 10.1021/mp300037t

Figure 4. Dependence of transgene expression on Definity® concentrations mediated by US exposure with simultaneous injection of pDNA + MB mixture via portal vein branch.

Figure 4

Different concentrations of Definity® (Vol%: 0~30%) were employed for gene delivery under the US exposure conditions of 1.1 MHz frequency, 2.7 MPa peak negative pressure, 20 cycle pulses, 13.9 Hz PRF, and 90 s total US exposure, the first 45 s of which were coincident with injection of pDNA and Definity®. In order to present the Definity® concentrations on a log scale (to better resolve the data at low Definity® concentrations), the true 0 Vol% Definity® data are plotted at an arbitrarily small value (0.001 Vol%) concentration as a graphic expedience. Error bars indicate the standard error of the mean (n=6).