. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: Trends Biochem Sci. 2012 Dec 3;38(1):12–19. doi: 10.1016/j.tibs.2012.10.007

Table 1.

Summary of Cdk phosphorylation events in Rb

Sites	Domain	Structural Effect	Biochemical Output
S249/T252	RbN	Unknown	Inhibits protein interactions with RbN
T356	RbIDL	C-terminal helix of RbN becomes disordered	Unknown
T373	RbIDL	Nucleates N-terminal pocket helix to induce RbN-pocket association	Inhibits E2F^TD and LxCxE binding to pocket domain
S608/S612	RbL	RbL binds pocket	Inhibits E2F^TD binding
S780	Pocket	Unknown	Unknown
S788/S795	RbC	Unknown	Inhibits RbC-E2F1^MB-UP^MB binding
S807/S811	RbC	Unknown	Might prime phosphorylation at other sites
T821/T826	RbC	Induces RbC binding to the pocket domain	Inhibits RbC-E2F1^MB-DP^MB binding and inhibits LxCxE binding to pocket domain.