Table 1.

Comparison of mean values (±standard deviation) of pharmacokinetic parameters of muscle and tumor regions for the 19 dynamic contrast-enhanced (DCE)-MRI experiments in our study with those from DCE-MRI studies in small rodents^a

Parameter	Ktrans/min−1	kep/min−1	ve	vp
Muscle (our study)	0.038 ± 0.025	0.66 ± 0.48	0.060 ± 0.014	0.033 ± 0.021
Muscle (literature)	0.044 ± 0.033b	0.55c	0.080 ± 0.040d	0.028 ± 0.008e
Tumor (our study)	0.082 ± 0.071	0.82 ± 0.80	0.121 ± 0.075	0.093 ± 0.051
Tumor f (literature)	0.062 ± 0.017	0.41c	0.15 ± 0.04	0.04 ± 0.01

^aReferences given in parentheses.

^bK^trans is the average value for perivertebral muscle in mice obtained from 2 separate contrast agent injections (16).

^ck_ep was calculated by Eq. 3, using values reported for K^trans and v_e in literature (16, 17).

^dv_e values are for rat skeletal muscle (16).

^ev_p is the average value obtained from 2 different limb muscles in rabbit (15).

^fValues for orthotopic BN472 breast tumor xenografts in Brown Norway rat (16).