FIGURE 6.

Serum IgM level and number of peripheral CD27⁺ memory B cells are highly correlated with mean corrected T₁ titer in NHL patients treated with rituximab-based chemotherapy. A, Table showing Spearman’s coefficients (ρ) and relative p values (P) for correlations among FACS parameters, serum Ig levels, and mean corrected T₁ titers for influenza vaccine in all subjects (ALL), control group (CTR), and patients (PAT) groups. The corrected T₁ titers for each strain are also shown for the patient group. *Number of B cells/μl; ^†percentage of B cells in PBMCs; ^‡number of CD27⁺ memory B cells/μl; ^§percentage of CD27⁺ memory B cells in PBMCs; ^||percentage of CD27⁺ memory B cells in B cells; ^¶mean corrected T₁ titers for H3N2, H1N1, and B strains. B, Three-dimensional scatter plot of IgM serum level, mean corrected T₁ titer, and number of peripheral CD27⁺ memory B cells. Intersections of the three vectors are represented in space as yellow spheres, connected to the three-dimensional regression plane (light purple surface) by lines representing least squares fitting.