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. 2012 Nov 20;137(4):271–281. doi: 10.1111/imm.12009

Figure 1.

Figure 1

Genomic organization of the antigen receptor loci in human beings. The maroon, green, purple and blue rectangles represent V, D, J and C segments, respectively and the blue ovals indicate enhancers. (a) The human IgH locus, located on chromosome 14 at band 14q32.33. It has 123 to 129 IgHV genes depending on haplotypes, 27 IgHD segments, and nine IgHJ segments and in the most frequent haplotype, 11 IgHC genes. (b) The human IgK locus located on the chromosome 2, at band 2p11.2. It consists of 76 IgKV genes, five IgKJ segments, and a unique IgKC gene. (c) The human IgL locus located on chromosome 22 at band 22q11.2. It consists of 73 to 74 IgLV genes, 7 to 11 IgLJ and 7 to 11 IgLC genes depending on the haplotypes. (d) The human TCRA locus located on chromosome 14 at band 14q11.2. It consists of 116 genes: 54 TCRAV, 61 TCRAJ and a unique TCRAC gene. TCRD locus is embedded in the TCRA locus, between the TCRAV and TCRAJ genes. Though represented in the figure as ‘TCRAV 54’, among the 54 V genes, five can be rearranged to either TCRAJ or TCRDD genes and therefore can be used in the synthesis of α or δ chains. (e) The human TCRB locus on chromosome 7 at 7q34, consisting of 64–67 TCRBV, 2 TCRBD, 14 TCRBJ and two TCRBC genes. (f) The human TCRG locus is on chromosome 7 at 7p14 and consists of 12–15 TCRGV, five TCRGJ and two TCRGC1 genes. The data presented are in accordance with IMGT (http://www.imgt.org).