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. 2012 Nov 20;137(4):317–325. doi: 10.1111/imm.12012

Figure 1.

Figure 1

Increased HLA-E mRNA levels in multiple sclerosis (MS) white matter lesions. Snap-frozen tissue from the largest identified lesion from each patient tissue block, established by myelin oligodendrocyte glycoprotein staining, was macrodissected and RNA was extracted as described in the Materials and methods. Increased levels (P = 0.0002; two-tailed) of HLA-E mRNA were detected in white matter lesions from MS patients (2.96 ± 0.39; n = 12) compared with controls (0.84 ± 0.14; n = 10). Data were normalized using X-prolyl aminopeptidase (aminopeptidase P) 1.