Figure 5.

CD8 cells in active lesions co-localize with HLA-E. More CD8⁺ cells were found in active lesions (a; P = 0.0228; Mann–Whitney U-test). Also, more HLA-E protein expression was detected in lesion tissue enriched with CD8⁺ cells. There was mild but positive correlation (r² = 0.2; P = 0.03) between the presence of CD8⁺ cells and HLA-E expression, suggesting that increased levels of HLA-E correlates with increased infiltration of CD8⁺ cells (b). Co-localization confirms presence of CD8⁺ cells (marked by asterisk) near HLA-E⁺ cells (c). Scale bar = 10 μm.