Table 1.
Characteristics of the study participants
| Cohort | FPD | MSM | Healthy | ||||
|---|---|---|---|---|---|---|---|
| Group | CD4+low * | CD4+high * | EC* | < 1 year | 1–3 years | > 3 years | Healthy |
| No. | 10 | 21 | 10 | 45 | 33 | 14 | 35 |
| Age (years) | 41·9 ± 5·0 | 48·1 ± 7·2 | 46·5 ± 7·1 | 28·0 ± 7·1 | 31·9 ± 8·6 | 34·0 ± 7·1 | 30·1 ± 5·4 |
| Gender (female/male) | 5/5 | 8/13 | 8/2 | 0/45 | 0/33 | 0/14 | 18/17 |
| CD4+ count (cells/μl) | 276 ± 49 | 566 ± 186 | 613 ± 133 | 384 ± 173 | 363 ± 112 | 352 ± 258 | n.a. |
| Viral load (copies RNA/ml) | 12 657 ± 110 144 | 11 058 ± 289 153 | <LDL† | 35 611 ± 44320 | 22 227 ± 47376 | 25 996 ± 33 140 | n.a. |
| Infection time (years) | 15·8 ± 1·3 | 16·4 ± 0·6 | 16·4 ± 0·3 | 0·5 ± 0·2 | 2·0 ± 0·7 | 5·2 ± 2·4 | n.a. |
| HLA-A*30/B*13/Cw*06 no. (freq)‡ | 4 (40%) | 8 (38%) | 5 (50%) | n.a. | n.a. | n.a. | n.a. |
All data displayed as mean ± standard deviation (SD).
*
The former plasma donors (FPD) cohort is divided by CD4+ cell count and by viral load: CD4+low: non-controllers with viral load > 10 000 copies RNA/ml, CD4 decline > 50 cells per year, and CD4+ cells count < 350 cells/μl; CD4+high: non-controllers with viral load > 10 000 copies RNA/ml, CD4 decline > 50 cells per year, and CD4+ cells count > 350 cells/μl; EC: elite controllers who keep viral load < LDL over 10 years.
†
LDL: low detection limit = 40 copies RNA/ml.
‡
Numbers and frequency of subjects who carried HLA-A*30/B*13/Cw*06 in three groups. HLA: human leucocyte antigen; MSM: men who have sex with men; n.a.: not available.