Figure 5. Contribution of K_IR and K_ATP channels to resting V_M in BPN and BPH mesenteric VSMCs.

The left graphs show recordings illustrating the effects of two different BaCl₂ concentrations (30 and 100 μm, A) and 100 μm pinacidil and 20 μm glibenclamide (B) in representative BPN and BPH cells. Both resting V_M and the amplitude of the drug-induced changes are clearly different between BPN and BPH cells. These differences were consistent and significant, as shown in the summary data on the bar graphs. n= 9–18 cells in each group, Student's unpaired t test. The inset in B (horizontal bar plot) shows the fraction of K_ATP channels that are open at resting membrane potential, calculated as 100 ×ΔV_{M,glibenclamide}/(ΔV_{M,glibenclamide}+ΔV_M,pinacidil). Each value is the mean ± SEM of 18 (BPN) and 16 (BPH) cells. **P < 0.01, ***P < 0.001