Figure 6. Contribution of KIR channels to vascular tone in mesenteric BPN and BPH arteries.
A, time course of the changes in diameter in a BPN artery subjected to the pressure protocol shown at the bottom. At each pressure value, increasing concentrations of BaCl2 were applied as indicated, to obtain a dose–response curve for the barium-induced contraction. Myogenic tone was clearly observed in this artery when pressure was raised from 40 to 120 or 100 mmHg. B, dose–response curves for barium are represented for the two experimental conditions (BPN, grey symbols; BPH, white symbols) and the two pressure values explored (40 mmHg, circles; 100 mmHg, squares). n= 7–8 arteries.