Figure 2. Effect of intravenous ascorbic acid (Vit C) on the change in systolic blood pressure (ΔSBP, A and E), diastolic blood pressure (ΔDBP, B and F), mean arterial pressure (ΔMAP, C and G) and heart rate (ΔHR, D and H) in patients with peripheral arterial disease (PAD) during bouts of one-leg, low-intensity rhythmic plantar flexion exercise.

Control data from Protocol 1 (grey dashed line) are included for reference. Mean data from the first 20 s of each exercise stage are presented. Data are mean ± SEM, n= 8, *P < 0.05 between treatments at a specific time point. INT = interaction.