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. Author manuscript; available in PMC: 2013 Dec 21.

Published in final edited form as: Chem Biol. 2012 Dec 21;19(12):1600–1610. doi: 10.1016/j.chembiol.2012.10.013

Table 1.

MIC of GE37468 variants produced in this study.

		MIC (μg/mL)^a
Variant	PTM	B. subtilis ^b	MW2^c	COL^d
GE37468	wild type	0.016	0.016	0.016
T2C	thiazole	0.0078	0.0078	0.0078
T2S	oxazole	0.016	0.016	0.016
F5Y		0.13	0.13	0.25
Y7F		0.063	0.063	0.13
I8P		0.063	0.031	0.063
I8L	γ-hydroxy	0.063	0.031	0.031
I8L	γ-mhP	0.031	0.016	0.031
I8S		0.25	0.13	0.13
I8T		0.063	0.031	0.063
I8V		0.25	0.063	0.13
I8A		0.063	0.031	0.063
S13A		0.25	0.25	0.25
S13G		0.5	0.5	0.5

^a

Minimum inhibitory concentrations determined by overnight serial dilution culture.

^b

Bacillus subtilis PY79.

^c

Methicillin-resistant S. aureus MW2.

^d

Methicillin-resistant S. aureus COL.

See Figure S5 for compound isolation.