Table 3.

Significant Clusters of Activation using a Three-way analysis of variance (ANOVA)

ANOVA	Cluster Location	BA	extent	F	Primary Peak (x,y,z)	Direction of significant post hoc analyses
Anticipation: Group × Prime × Valence Three-way ANOVA
Interaction group × prime × valence	Right superior parietal lobule	7	632	11.38	56, −42, 50	Interaction group × prime; F(46)=4.17, p=0.047 Interaction prime × valence; F(46)=9.49, p=0.003  Group Differences: Loss after prime; BD>HC, p=0.006 Loss after control; HC>BD, p=0.006  Prime Differences: HC; Gain; prime>control, p=0.021 HC; Loss; control>prime, p=0.001 BD; Loss; prime>control, p=0.013  Valence Differences: HC; Prime; gain>loss, p=0.001 HC; Control; loss>gain, p=0.015
	Left inferior parietal lobule	40	445	9.28	−50, −48, 56	Main effect of prime; prime>control, F(46)=8.76, p=0.005  Group Differences: Loss after prime; BD>HC, p=0.016 Loss after control; HC>BD, p=0.014  Prime Differences: HC; Gain; prime>control, p=0.005 BD; Loss; prime>control, p=0.006  Valence Differences: HC; Prime; gain>loss, p=0.009 HC; Control; loss>gain, p=0.022
	Left middle frontal gyrus	10	617	12.01	−43, 56, −3	Group Differences: Loss after control; HC>BD, p=0.003  Prime Differences: HC; Loss; control>prime, p=0.039 BD; Loss; prime>control, p=0.015  Valence Differences: HC; Control; loss>gain, p=0.002 BD; Control; gain>loss, p=0.013
	Thalamus		226	11.46	−3, 31, 2	Main effect of valence; prime>control, F(46)=5.04, p=0.030  Group Differences: Gain after prime; HC>BD, p=0.009  Prime Differences: BD; Gain; control>prime, p=0.012  Valence Differences: HC; Control; gain>loss, p=0.004 BD; Control; gain>loss, p=0.010
	Right inferior temporal gyrus	20	197	10.26	58, −36, −15	Main effect of prime; prime>control, F(46)=4.17, p=0.048 Main effect of valence; gain>loss, F(46)=4.43, p=0.041 Interaction of prime × valence; F(46)=3.87, p=0.055  Group Differences: Gain after control; BD>HC, p=0.016  Prime Differences: HC; Gain; prime>control, p=0.013  Valence Differences: HC; Prime; gain>loss, p=0.019 BD; Control; gain>loss, p=0.050
Feedback: Group × Prime × Valence Three-way ANOVA
Interaction group × prime × valence	Right inferior parietal lobule	40	409	17.52	49, •43, 28	Group Differences: Loss after prime; HC>BD, p=0.006 Loss after control; HC>BD, p=0.035  Prime Differences: HC; Gain; prime>control, p=0.035 BD; Loss; control>prime, p=0.008  Valence Differences: HC; Control; gain>loss, p=0.012 BD; Prime; gain>loss, p=0.008
	Right superior frontal gyrus	8	1101	13.79	7, 24, 49	Main effect of valence; gain>loss, F(46)=8.75, p=0.005  Group Differences: Loss after control; BD>HC, p=0.003  Prime Differences; HC; Gain; control>prime, p=0.024 HC; Loss; prime>control, p=0.035  Valence Differences: HC; Control; gain>loss, p<0.001 BD; Prime; gain>loss, p=0.028
	Thalamus		377	11.75	•3, •13, 4	Main effect of group; HC>BD, F(46)=4.10, p=0.049 Main effect of valence; gain>loss, F(46)=4.48, p=0.04  Group Differences: Loss after prime; HC>BD, p>0.001 Prime Differences: BD; Loss; control>prime, p=0.019  Valence Differences: BD; Prime; gain>loss, p=0.001

Note: BA = Brodmann Area; BD = Adolescents with Bipolar I Disorder; HC = Healthy controls.