Table 4.

Significant Clusters of Activation using a Two-way analysis of variance (ANOVA)

ANOVA	Cluster Location	BA	extent	Direction of posthoc t-test	Posthoc t-test p-value	F	Primar y Peak (x,y,z)
Anticipation Gain ANOVA
Main effect of Group	Right orbitomedial frontal cortex	10	403	BD>HC	p=0.003	9.94	11, 55, 14
	Right angular gyrus	39	202	HC>BD Prime>control	p=0.001 p=0.02	11.88 5.53	31, −65, 27
	Left angular gyrus	39	233	HC>BD Prime>control	p=0.005 p=0.013	8.92 6.73	−31, −63, 18
Main effect of prime	Left middle frontal gyrus	6	1363	Prime>control	p<0.001	20.45	−37, 11, 57
	Left inferior parietal lobule	40	1271	Prime>control	p<0.001	14.67	−52, −44, 43
	Right superior parietal lobule	7	808	Prime>control	p=0.002	10.44	29, −69, 55
	Right superior frontal gyrus	8	454	Prime>control	p=0.001	12.93	41, 24, 49
	Right middle temporal gyrus	21	371	Prime>control	p=0.001	12.02	66, −28, −14
	Left inferior occipital gyrus	18	223	Prime>control	p=0.001	12.39	−43, −84, −3
	Right parahippocampal gyrus	30	207	Prime>control	p=0.002	10.45	29, −54, 58
	Right precentral gyrus	6	205	Prime>control	p=0.001	11.98	60, 5, 31
	Left orbitofrontal gyrus	11	203	Prime>control	p=0.001	12.53	−29, 34, −17
Interaction of group × prime	Subgenual cingulate	25	213	HC>BD	p<0.001	14.97	−13, 22, −14
Anticipation Loss ANOVA
Main effect of group	No significant clusters identified				p>0.05
Main effect of prime	Right posterior cingulate	31	408	Control>Prime	p=0.002	10.34	1, −39, 31
	Right inferior parietal lobule	40	491	Prime>control	p<0.001	14.38	62, −29, 46
	Right caudate		249	Prime>control	p=0.002	11.19	15, 16, 16
Interaction of group × prime	Right inferior parietal lobule	40	1083	BD>HC	p<0.001	17.30	54, −42, 52
	Right middle frontal gyrus	10	894	BD>HC	p<0.001	15.54	41, 44, 16
	Left inferior parietal lobule	40	823	BD>HC	p=0.001	11.98	−49, −50, 56
	Left parahippocampal gyrus	19	381	HC>BD	p<0.001	18.47	−35, −43, −3
	Left middle frontal gyrus	46	372	BD>HC	p=0.001	13.71	−43, 42, 15
	Right middle frontal gyrus	6	223	BD>HC	p=0.002	10.40	50, 1, 52
	Left middle temporal gyrus	20	195	BD>HC	p=0.002	11.38	−60, −45, −11
Feedback Gain ANOVA
Main effects and Interactions	No significant clusters identified				p>0.05
Feedback Loss ANOVA
Main effect of group	Right superior frontal gyrus	6	446	BD>HC Prime>control	p<0.001 p=0.042	15.08 4.39	7, 30, 55
	Right orbitofrontal gyrus	47	355	BD>HC	p<0.001	17.81	43, 28, −7
Main effect of prime	Left parahippocampal gyrus	30	211	Control>Prime	p<0.001	27.11	−21, −48, 6
Interaction of group × prime	Right superior frontal gyrus	6	214	HC>BD	p=0.001	11.95	5, 12, 53

Note: BA = Brodmann Area; BD = Adolescents with Bipolar I Disorder; HC = Healthy controls.