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. Author manuscript; available in PMC: 2013 Dec 21.
Published in final edited form as: Cell. 2012 Dec 13;151(7):1457–1473. doi: 10.1016/j.cell.2012.11.026

Figure 2. YAP1 is essential for tumorigenicity of β-catenin dependent cancer cell lines.

Figure 2

(A) Proliferation and (B) AI growth of the indicated cancer cell lines following suppression of YAP1. Classification of β-catenin activity in each cell line is noted. (C) Proliferation, (D) AI growth and (E) expression of YAP1 in HuTu80 cell lines overexpressing wild type (WT) YAP1 and the indicated YAP1-specific or control (shLacZ) shRNAs. (F) Effects of suppressing YAP1 on orthotopic colon tumors. (G) YAP1 expression in tumors shown in (F). (H-J) HA1EM cells expressing β-catenin or YAP1 and YAP1- or β-catenin-specific shRNAs. (H) AI growth, (I) proliferation or (J) protein levels. In (H) inset shows representative images from AI growth assay. Data presented as mean ± SD for 3 independent experiments. See also Figure S2 and S3.