Immunostaining for hyperphosphorylated tau (AT8) in case 8. (A) There are 2 tufted astrocytes (arrowheads) and a glial cytoplasmic inclusion (GCI) (open arrow) in the prefrontal cortex. (B) There are 5 tufted astrocytes (arrowheads), a neurofibrillary tangle ([NFT], arrow) and a GCI (open arrow) in the precuneus. (C) A tufted astrocyte (arrowhead) in the motor cortex. (D) A tufted astrocyte (arrowhead) and an NFT (arrow) in the head of the caudate nucleus. Magnifications: A, B, D, 200x; C, 630x.