Table 1.

Demographic Features and Clinical Features of Essential Tremor Patients

Case Number	Gender	Age at Death (y)	Age at ET Onset (y)	Duration of ET at Death (y)	Spiral Ratings1	HT, JT, VT	Additional Comments on Clinical Features of ET	ET Medications	Family History of ET
1	F	89	56	33	R = 2 L = 2	HT, JT	None	Prim, Dz	None
2	M	98	88	10	R = 3 L = 3	None	None	Prim, Top	Sister
3	F	92	41	51	R = 2 L = 2	HT	HT > arm tremor. “Yes- yes” HT.	Gab	Sister
4	F	99	53	46	R = 3 L = 3	HT	None	None	Son, Granddaughter
5	F	85	55	30	R = 1.5 L = 2	JT, VT	Head > arm tremor. Forehead tremor	Prop, Prim Cz	None
6	M	77	35	42	R = 2 L = 1	None	None	Prop, Gab2	Mother
7	F	74	36	38	R = 3 L = 3	HT, JT, VT	None	Prop, Prim, Top, Dz, Cz, Mir	Father, Brother, Sister
8	F	88	32	56	R = 2.5 L = 3	HT, JT, VT	None	Prop, Prim, Gab, Dz, botulinum toxin injections3	Mother, Sister, Niece
9	F	83	8	75	R = 2 L = 2	JT	Forehead tremor.	Yes, but details not known	Father, Son, Sister,
10	F	87	74	13	R = 2 L = 1.5	None	Lip tremor None	Prim	Grandfather Mother
11	F	91	55	36	R = 1 L = 2	HT	None	Prop, Top, Gab	None

Cz = clonazepam, Dz = diazepam, ET = essential tremor, F = female, gab = gabapentin, HT = head (i.e., neck) tremor, JT = jaw tremor, L = left arm, M = male, Mir = mirtazapine, Prim = primidone, Prop = propranolol, R = right arm, Top = topiramate, VT = voice tremor, y = years

¹R = mean of two 0 – 3 ratings from right hand; L = mean of two 0- 3 ratings from left hand. Washington Heights Inwood Genetic Study of Essential Tremor rating scale (0 = none, 1 = mild, 2 = moderate, 3 = severe).

²Case 6 also had left thalamic deep brain stimulation surgery for tremor control (at age 74).

³Case 8 also had left gamma knife radiosurgical thalamotomy for ET (age 83) and right Vim brain stimulation surgery for tremor (age 84).