Table 3.
Postmortem Fiindings
| Case # | Tauopathic changes / PSP distribution1 | Tufted Astrocytes2 | Neuronal loss3 | LBs NSPD | Postmortem PD Diagnosis | NIA-Reagan Criteria for AD | Torpedo Count | PC Count | Basket Process Rating | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNc | STN | GP | |||||||||
| D | |||||||||||
| 1 | 1+ | 1+ | 2 | 0 | 0 | 0 | No | Low | 14 (LH&E) | 7.4 | 3 |
| 1 | 30 (Biel) | ||||||||||
| 2 | 1+ | 1+ | 2 | 0 | 0 | 0 | No | 0 | 6 (LH&E) | 6.6 | NA |
| 1 | NA (Biel) | ||||||||||
| 3 | 2+ | 2+ | 2 | 0 | 0 | 0 | No | 0 | 6 (LH&E) | 6.9 | 2.5 |
| 1 | 24 (Biel) | ||||||||||
| 4 | 1+ | 1+ | 1 | 0 | 0 | 0 | No | Low | 23 (LH&E) | 4.6 | NA |
| 1 | NA (Biel) | ||||||||||
| 5 | 1+ | 1+ | 1 | 0 | 0 | 0 | No | Low | 4 (LH&E) | 12.6 | 3 |
| 1 | 15 (Biel) | ||||||||||
| 6 | 2+ | 2+ | 2 | 1 | 1 | 4 | Yes4 | 0 | 20 (LH&E) | 5.5 | 1 |
| 1 | 37 (Biel) | ||||||||||
| 7 | 1+ | 1+ | 1 | 0 | 1 | 0 | No | Low | 7 (LH&E) | 9.2 | NA |
| 0 | NA(Biel) | ||||||||||
| 8 | 2+ | 2+ | 2 | 0 | 1 | 0 | No | Low | 13 (LH&E) | 9.0 | 3 |
| 0 | 27 (Biel) | ||||||||||
| 9 | 1+ | 2+ | 2 | 0 | 0 | Yes5 | No | 0 | 5 (LH&E) | 9.7 | 2 |
| 0 | 15 (Biel) | ||||||||||
| 10 | 3+ | 3+ | 3 | 3 | 3 | 0 | No | Intermediat | 13 (LH&E) | 7.5 | NA |
| 2 | e | NA (Biel) | |||||||||
| 11 | 2+ | 2+ | 2 | 0 | 0 | 0 | No | 0 | 10 (LH&E) | 6.8 | 2.5 |
| 1 | 21 (Biel) | ||||||||||
AD = Alzheimer disease, Biel = Bielschowsky impregnation, D= dentate nucleus (cerebellum), GP = globus pallidus, LBs = Lewy bodies, LH&E = Luxol fast blue counterstained with hematoxylin and eosin, NA = not available, NSPD = neuropathologic stage of Parkinson disease related changes, PC = Purkinje cell count, PD = Parkinson disease, PSP = progressive supranuclear palsy, SNc = substantia nigra pars compacta, STN = subthalamic nucleus
refers to globose neuronal tangles found in at least 7 of the following 9 sites: cerebral cortex, neostriatum, globus pallidus, subthalamic nucleus, red nucleus, pars compacta of the substantia nigra, pontine nuclei, inferior olivary nucleus, and dentate nucleus of the cerebellum. 1+ (1 per 100X microscopic field), 2+ (up to 3 per 100X microscopic field) 3+ (> 3 per 100X microscopic field).
Relative densities of tufted astrocytes within the cerebral cortex, neostriatum, globus pallidus, amygdala, and subthalamic nucleus. 1+ (1 per 100X microscopic field), 2+ (up to 3 per 100X microscopic field) 3+ (> 3 per 100X microscopic field).
Neuronal loss was rated as 0 (none), 1 (mild), 2 (moderate), 3 (severe).
Case 6 had a postmortem diagnosis of both PSP and PD. The neuropathologic stage of PD related changes (NSPD), as proposed by Braak and Braak, was 4 out of 6.
Lewy body-containing neurons confined to the substantia innominata and pars compacta of the substantia nigra, not found within the dorsal nucleus of vagus or within the nucleus coeruleus, thus the distribution of Lewy body-containing neurons in this brain does not recapitulate the NSPD scheme as proposed by Braak and Braak.