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. Author manuscript; available in PMC: 2013 Dec 20.
Published in final edited form as: Neuron. 2012 Dec 20;76(6):1189–1200. doi: 10.1016/j.neuron.2012.10.036

Figure 7. Transient increase in theta oscillatory powers in acute phase.

Figure 7

(A) Field activity in the CA1-dentate axis of hippocampus during awake immobility and exploration (recorded simultaneously from 7 sites at 50–100 μm tip intervals). Arrows in the granule cell layer or hilar region (electrodes #6 & #7) of dentate gyrus indicate dentate spikes during immobility in control mice. LFP activity containing dentate spikes and large theta-gamma oscillations, typical patterns of which are in electrode #7, were analyzed further. (B) Averaged intensity of 7–12 Hz theta frequency LFP powers during exploration recorded just before DT injection (pre, black), on day 7 (7 day, red), and 4-weeks (blue) after treatment from the same electrode (located in the dentate gyrus) in the mutant mouse. (C) The ratio change of theta power (7–12 Hz) intensity across days (pre DT levels as 100%). Mutant mice (n=3, red line) show a transient increase in the theta frequency power at post-DT day 7, whereas the controls do not (n=3, black line), *p<0.05.