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. Author manuscript; available in PMC: 2012 Dec 26.
Published in final edited form as: Org Biomol Chem. 2010 Sep 6;8(23):5431–5441. doi: 10.1039/c0ob00482k

Scheme 2.

Scheme 2

Syntheses of 2a and 2b. a) NaH, DME, 2-thiophene-carboxaldehyde, 88%; b) POCl3, DMF, reflux, 98%; c) ethylene glycol, TsOH (catalyst), benzene, Dean–Stark, reflux, 20% for 14a; d) di(2-picolyl)amine, NaBH(OAc)3, rt, 58% for 15a; e) HCl–THF–H2 O, rt; f) NaH, dimethoxyethane, 5, rt, 46% for 2a and 12% for 2b in two steps.