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. 2012 Nov 15;186(10):1044–1050. doi: 10.1164/rccm.201204-0622OC

Figure 5.

Figure 5.

Ex vivo antibacterial function of wild-type and A2B–/– neutrophils. Ex vivo assays were done to compare wild-type and A2B–/– bone marrow neutrophils. (A) Relative expression of A2BR mRNA in resting bone marrow neutrophils after exposure to bacteria; (B) combined (extracellular and intracellular) bactericidal activity, *P < 0.01 (Mann-Whitney); (C) phagocytic capacity; (D) intracellular bactericidal activity; (E) neutrophil extracellular trap (NET) production, *P < 0.05 (one-way analysis of variance); (F) oxidative burst. Data for all panels represent means ± SEM of triplicates or quadruplicates representative of two to four experiments for each panel. Horizontal line in (B) and (D) represents initial bacterial load per well. PMA = phorbol myristate acetate; PMN = polymorphonuclear neutrophils; Kp = Klebsiella pneumoniae; WT = wild type.