TABLE 2.

Independent effects of baseline clinical risk factors on change in FEV₁% predicted

	Full Model (R2 = 0.59)		Reduced Model (R2 = 0.56)
Baseline Risk Factor	ParamEst (SE)	P Value	ParamEst (SE)	P Value
Age	−0.14 (0.07)	0.06	−0.16 (0.06)	0.01
Gender (female)	1.9 (0.4)	<0.01	1.8 (0.3)	<0.01
FEV1% predicted	0.03 (0.01)	0.04	0.03 (0.01)	0.01
CF genotype (high risk)*	−0.01 (0.39)	0.97
BMI percentile	0.01 (0.01)	0.34
Pseudomonas aeruginosa infection†	−0.26 (0.42)	0.55
Staphylococcus aureus infection†	−0.28 (0.42)	0.51

^*Subjects were classified as having a “high risk” genotype if they had two identified class I, II or III CF mutations. Subjects with at least one class IV, V, or unidentified mutation were classified as having a “low risk” genotype.

^†Infection status was based on having a positive respiratory culture for P. aeruginosa or S. aureus during any of the four study visits.