Table 1.
Functions of heat shock proteins.
| Heat shock protein molecular weight (kilodaltons) | Function | Pathologic associations |
|---|---|---|
| 60 | Protein folding | Atherosclerosis |
| Protein unfolding | Rheumatoid arthritis | |
| Polypeptide assembly | Systemic sclerosis | |
| Protein translocation across membranes | Schizophrenia | |
| Diabetes mellitus | ||
|
| ||
| 10 | Cofactor for HSP 60 | Cardiovascular disease |
|
| ||
| 27 | Competes for uptake with lipids | Atherosclerosis |
| Estrogen receptor-β-associated protein | ||
|
| ||
| 70 | Protein folding | Atherosclerosis |
| Protein unfolding | Leprosy | |
| Degradation of misfolded or denatured proteins | Tuberculosis | |
| Assembly of new proteins | ||
| Translocation of proteins across membranes | ||
|
| ||
| 90 | Molecular chaperone involved in protein folding and activation | Atherosclerosis |
| Systemic lupus erythematosus | ||