Table 6.
Multivariate Relative Riska of Incident Hearing Loss According to Regular Use (≥2 Times/Week) of Individual and Multiple Analgesic Agents, Nurses' Health Study II, 1995–2009
| Analgesic(s) Used | No. of Cases | Relative Risk | 95% Confidence Interval |
|---|---|---|---|
| No regular use | 5,315 | 1.00 | |
| Aspirin only | 1,275 | 1.01 | 0.95, 1.08 |
| Ibuprofen only | 1,653 | 1.17 | 1.11, 1.24 |
| Acetaminophen only | 483 | 1.09 | 0.99, 1.19 |
| Aspirin + ibuprofen | 463 | 1.16 | 1.05, 1.27 |
| Ibuprofen + acetaminophen | 408 | 1.28 | 1.16, 1.42 |
| Aspirin + acetaminophen | 243 | 1.23 | 1.08, 1.40 |
| All 3 analgesics | 172 | 1.34 | 1.15, 1.56 |
a Adjusted for age; race; body mass index; alcohol consumption; physical activity; intakes of folate, vitamin B12, magnesium, potassium, and vitamin A; smoking status; hypertension; and diabetes.