Table 2.
Equivalent Detectable Odds Ratios for Genetic Tests
| Allele Frequency | Frequencies |
Per-Allele Odds Ratios |
||
|---|---|---|---|---|
| Subtype A, % | Subtype B, % | Overall | Subtypesa | |
| 0.10 | 20 | 80 | 1.20 | 1.29 (1.18) |
| 0.10 | 20 | 80 | 1.50 | 1.73 (1.45) |
| 0.10 | 20 | 80 | 2.00 | 2.42 (1.90) |
| 0.10 | 50 | 50 | 1.20 | 1.24 (1.17) |
| 0.10 | 50 | 50 | 1.50 | 1.58 (1.42) |
| 0.10 | 50 | 50 | 2.00 | 2.11 (1.90) |
| 0.30 | 20 | 80 | 1.20 | 1.31 (1.18) |
| 0.30 | 20 | 80 | 1.50 | 1.83 (1.43) |
| 0.30 | 20 | 80 | 2.00 | 2.83 (1.85) |
| 0.30 | 50 | 50 | 1.20 | 1.24 (1.16) |
| 0.30 | 50 | 50 | 1.50 | 1.61 (1.40) |
| 0.30 | 50 | 50 | 2.00 | 2.26 (1.78) |
| 0.50 | 20 | 80 | 1.20 | 1.32 (1.17) |
| 0.50 | 20 | 80 | 1.50 | 1.94 (1.42) |
| 0.50 | 20 | 80 | 2.00 | 3.64 (1.80) |
| 0.50 | 50 | 50 | 1.20 | 1.25 (1.16) |
| 0.50 | 50 | 50 | 1.50 | 1.64 (1.38) |
| 0.50 | 50 | 50 | 2.00 | 2.43 (1.70) |
a The minimum heterogeneity of per-allele odds ratios required (subtype A; subtype B in parentheses) for a strategy of comparing subtypes individually versus controls in order to possess equivalent power to an overall test of association.