Table 3.

Summary of Individual SNPs Significantly Associated With Blood Pressure Response to Sodium Interventions, GenSalt Study, China, 2003–2005

SNP	Minor Allele	Minor Allele Frequency	Response to Low Sodium								Response to High Sodium
			Systolic Blood Pressure			Diastolic Blood Pressure			Mean Arterial Pressure		Systolic Blood Pressure		Diastolic Blood Pressure		Mean Arterial Pressure
			z Statistic	P Value	Q Valuea	z Statistic	P Value	Q Valuea	z Statistic	P Value	z Statistic	P Value	z Statistic	P Value	z Statistic	P Value
BDKRB2b
rs11847625	C	0.20	−3.798	1.4 × 10−4	0.03	−1.210	0.23		−2.420	0.02	2.992	2.8 × 10−3	0.415	0.68	1.332	0.18
ECE1b
rs213011	A	0.37	0.846	0.40		−3.232	1.2 × 10−3	0.047	−2.127	0.03	−0.607	0.54	0.613	0.54	0.454	0.65
rs169884	A	0.39	0.409	0.68		−3.499	4.7 × 10−4	0.047	−2.476	0.01	−0.290	0.77	0.855	0.39	0.756	0.45
rs84853	T	0.39	0.218	0.83		−3.623	2.9 × 10−4	0.047	−2.675	7 × 10−3	0.069	0.95	0.992	0.32	0.980	0.33
rs213012	T	0.38	0.638	0.52		−3.191	1.4 × 10−3	0.047	−2.151	0.03	−0.161	0.87	0.911	0.36	0.848	0.40
rs213014	C	0.40	0.615	0.54		−3.265	1.1 × 10−3	0.047	−2.205	0.03	−0.315	0.75	1.012	0.31	0.853	0.39
rs213018	A	0.40	0.465	0.64		−3.204	1.4 × 10−3	0.047	−2.208	0.03	−0.356	0.72	0.887	0.37	0.721	0.47
rs213025	A	0.38	0.594	0.55		−3.154	1.6 × 10−3	0.047	−2.120	0.03	−0.318	0.75	0.993	0.32	0.841	0.40

Abbreviations: GenSalt, Genetic Epidemiology Network of Salt Sensitivity; SNP, single nucleotide polymorphism.

^a False discovery rate Q values that are less than 0.05 are provided.

^b Gene symbols and their expanded names: BDKRB2, bradykinin receptor B2 gene; ECE1, endothelin converting enzyme 1 gene.