Fig. 6.

4-year-old boy with Coats disease presented with leukocoria in the left eye and was suspected to have retinoblastoma. a Axial CISS MRI demonstrates exudate with high signal intensity due to cholesterol and lipid-laden subretinal exudate (straight arrow) causing massive retinal detachment (curved arrows). b Axial pre-contrast-enhanced and c post-contrast-enhanced T1W MR image show typical lack of enhancement of subretinal fluid with linear enhancement at the border of exudate and vitreous (arrows). d Transverse US shows tiny echogenic “speckles” likely due to lipoproteinaceous exudate floating in subretinal space. As in this example, microcalcifications are usually absent. e H&E staining of a paraffin section through the optic nerve with subretinal exudate (pink) and severely detached retina (arrow). f H&E staining of exudate shows cholesterol crystals (arrow)