Table 2.
Differences in inflammatory markers between patients with a Th1(+) response to MBP at 90 days and those without.
| Th1(+) response to MBP | |||
|---|---|---|---|
| 90 days: | yes N=19 |
no N=47 |
P |
| leukocytes (thou/microL) | 7.73 (5.94, 9.41) | 6.94 (5.39, 7.99) | 0.111 |
| neutrophils (thou/microL) | 4.44 (3.36, 6.51) | 4.01 (3.09, 5.29) | NS |
| lymphocytes (thou/microL) | 1.75 (1.37, 2.14) | 1.73 (1.33, 2.14) | NS |
| monocytes (thou/microL) | 0.57 (0.44, 0.66) | 0.50 (0.41, 0.66) | NS |
| HMGB1 (ng/mL) | 5.70 (2.51, 8.11) | 3.27 (2.12, 4.49) | 0.030 |
| CRP (mg/L) | 8.10 (0.80, 21.1) | 1.90 (0.60, 3.92) | 0.036 |
MBP=myelin basic protein, HMGB=high mobility group box, CRP=C reactive protein, NS=not significant. Th1(+) response to MBP is a response greater than that seen in 75% of the control population.5