Table 5.
Cox analysis of metastasis-free survival (MFS) in the molecular subtypes (ER+/HER; ER-/HER2-; HER2+) according to Desmedt and co-workers [[31]]
| Mainz cohort(n=158) | Rotterdam cohort(n=178) | Transbig cohort(n=186) | Combined cohorts(n=522) | ||
|---|---|---|---|---|---|
| A. Univariate analysis | |||||
| ER+/HER2- | |||||
| AURKA |
P-value |
0.011 |
<0.001 |
<0.001 |
<0.001 |
| HR |
1.786 |
2.916 |
2.174 |
2.100 |
|
| 95%-CI |
1.144-2.787 |
2.022-4.206 |
1.491-3.171 |
1.700-2.594 |
|
| |
Mainz cohort(n=23) |
Rotterdam cohort(n=58) |
Transbig cohort(n=59) |
Combined cohorts(n=140) |
|
| ER-/HER2- | |||||
| AURKA |
P-value |
0.497 |
0.808 |
0.924 |
0.993 |
| HR |
1.534 |
1.103 |
0.967 |
1.002 |
|
| 95%-CI |
0.446-5.282 |
0.498-2.443 |
0.483-1.934 |
0.637-1.577 |
|
| |
Mainz cohort(n=19) |
Rotterdam cohort (n=50=) |
Transbig cohort (n=35) |
Combined cohorts (n=104) |
|
| HER2+ | |||||
| AURKA | P-value |
0.298 |
0.840 |
0.100 |
0.402 |
| HR |
2.303 |
1.088 |
0.439 |
0.785 |
|
| 95%-CI | 0.478-11.091 | 0.481-2.461 | 0.165-1.171 | 0.446-1.382 | |
AURKA is associated with MFS in the estrogen receptor positive but not in the estrogen receptor negative subtypes. A. Univarate analysis.