Figure 4. Amino acid sequence alignment of the Grx domain of mouse TGR with mono- and dithiol Grx from various organisms.

The active site residues of Grx are highlighted with a red rectangle, and the residues involved in the interaction with glutathione are within black rectangles. Positive and negative charged amino acids are marked with blue and red colour, respectively. Cysteines residues are marked in green. Sequences abbreviation: HS, Homo sapiens; SM, Schistosoma mansoni; XL, Xenopus laevis; MM, Mus musculus; DR, Danio rerio; EC, Escherichia coli.