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. 2004 Mar;48(3):946–953. doi: 10.1128/AAC.48.3.946-953.2004

FIG. 1.

FIG. 1.

(A1 and B1) Ciprofloxacin (A1) and moxifloxacin (B1) pharmacokinetics and pharmacodynamic effect on S. maltophilia Sm206 during simulation of twice-daily oral administration of 750 mg of ciprofloxacin over 48 h and once-daily oral administration of 400 mg of moxifloxacin, respectively, in the in vitro PK/PD model (mean, n = 3). Symbols: ▪, CCp concentration-time curve; □, PCp concentration-time curve; ▵, control growth curve; ⋄, killing and regrowth curve. (A2 and B2) Emergence of Sm206 ciprofloxacin (A2)- and moxifloxacin (B2)-resistant mutants during the corresponding simulations (mean percentage of viable counts; n = 3). Bars: ▪, control; ▤, resistant to 1 times the MIC; ▥; resistant to 4 times MIC; ▧, resistant to 16 times the MIC.