TABLE 1.
Parameter | Mean value ± SD (n = 3) |
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Ciprofloxacin |
Moxifloxacin |
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Dosing interval |
Human data (n = 6) | Dosing interval |
Human data (n = 12) | |||||
0-12 h | 12-24 h | 24-36 h | 36-48 h | 0-24 h | 24-48 h | |||
Cmax (μg/ml) | 3.08 ± 0.43 | 3.39 ± 0.06 | 3.43 ± 0.21 | 3.60 ± 0.17 | 2.94 ± 0.42a | 2.45 ± 0.11 | 2.82 ± 0.23 | 2.5 ± 1.29c |
Tmax (h) | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.2 ± 0.5a | 0.90 ± 0.00 | 0.90 ± 0.00 | 2 (0.5-6.0)c |
Cres. (μg/ml) | 0.29 ± 0.02 | 0.29 ± 0.10 | 0.34 ± 0.05 | 0.37 ± 0.08 | 0.36 ± 0.02 | 0.39 ± 0.06 | ||
Ka (h−1) | 2.72 ± 0.47 | 2.68 ± 0.44 | 2.37 ± 0.10 | 2.18 ± 0.13 | 2.70 ± 1.22b | 2.09 ± 0.80 | 1.99 ± 0.68 | 2-3c |
t1/2β (h) | 4.59 ± 0.09 | 4.77 ± 1.03 | 5.19 ± 0.33 | 5.15 ± 0.59 | 4.70 ± 0.83a | 16.5 ± 0.5 | 16.9 ± 2.9 | 15.6 ± 1.15c |
MRTd (h) | 6.72 ± 0.10 | 6.81 ± 0.99 | 7.57 ± 0.47 | 7.73 ± 0.83 | 5.28 ± 0.89a | 22.0 ± 0.7 | 22.5 ± 3.8 | |
AUC (h × μg/ml) | 11.5 ± 0.6 | 12.5 ± 1.2 | 12.8 ± 0.6 | 14.2 ± 1.6 | 11.53 ± 2.21a | 17.6 ± 0.3 | 19.3 ± 0.5 | |
CLtot/F (liter) | 56.0 ± 2.5 | 52.1 ± 8.7 | 48.9 ± 3.9 | 44.6 ± 6.9 | 45.0 ± 5.9a | 15.3 ± 0.3 | 13.7 ± 1.8 | |
V/F (liter) | 371.1 ± 14.3 | 350.8 ± 31.3 | 365.1 ± 10.3 | 328.2 ± 11.9 | 304.0 ± 61.0a | 364.4 ± 5.1 | 324.0 ± 34.1 | |
Correlation coefficient | 0.996 ± 0.003 | 0.998 ± 0.000 | 0.996 ± 0.000 | 0.993 ± 0.006 | 0.996 ± 0.005 | 0.997 ± 0.002 |