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. 2004 Mar;48(3):946–953. doi: 10.1128/AAC.48.3.946-953.2004

TABLE 1.

Mean pharmacokinetic parameters for the PCp after simulation with twice-daily oral administration of 750 mg of ciprofloxacin and once daily oral administration of 400 mg of moxifloxacin over 48 h and the corresponding human reference data.

Parameter Mean value ± SD (n = 3)
Ciprofloxacin
Moxifloxacin
Dosing interval
Human data (n = 6) Dosing interval
Human data (n = 12)
0-12 h 12-24 h 24-36 h 36-48 h 0-24 h 24-48 h
Cmax (μg/ml) 3.08 ± 0.43 3.39 ± 0.06 3.43 ± 0.21 3.60 ± 0.17 2.94 ± 0.42a 2.45 ± 0.11 2.82 ± 0.23 2.5 ± 1.29c
Tmax (h) 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 1.2 ± 0.5a 0.90 ± 0.00 0.90 ± 0.00 2 (0.5-6.0)c
Cres. (μg/ml) 0.29 ± 0.02 0.29 ± 0.10 0.34 ± 0.05 0.37 ± 0.08 0.36 ± 0.02 0.39 ± 0.06
Ka (h−1) 2.72 ± 0.47 2.68 ± 0.44 2.37 ± 0.10 2.18 ± 0.13 2.70 ± 1.22b 2.09 ± 0.80 1.99 ± 0.68 2-3c
t1/2β (h) 4.59 ± 0.09 4.77 ± 1.03 5.19 ± 0.33 5.15 ± 0.59 4.70 ± 0.83a 16.5 ± 0.5 16.9 ± 2.9 15.6 ± 1.15c
MRTd (h) 6.72 ± 0.10 6.81 ± 0.99 7.57 ± 0.47 7.73 ± 0.83 5.28 ± 0.89a 22.0 ± 0.7 22.5 ± 3.8
AUC (h × μg/ml) 11.5 ± 0.6 12.5 ± 1.2 12.8 ± 0.6 14.2 ± 1.6 11.53 ± 2.21a 17.6 ± 0.3 19.3 ± 0.5
CLtot/F (liter) 56.0 ± 2.5 52.1 ± 8.7 48.9 ± 3.9 44.6 ± 6.9 45.0 ± 5.9a 15.3 ± 0.3 13.7 ± 1.8
V/F (liter) 371.1 ± 14.3 350.8 ± 31.3 365.1 ± 10.3 328.2 ± 11.9 304.0 ± 61.0a 364.4 ± 5.1 324.0 ± 34.1
Correlation coefficient 0.996 ± 0.003 0.998 ± 0.000 0.996 ± 0.000 0.993 ± 0.006 0.996 ± 0.005 0.997 ± 0.002
a

Fourtillan (17).

b

Crump et al. (10).

c

Stass and Kubitza (33).

d

MRT, mean residence time.