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. 2012 Dec 26;7(12):e52833. doi: 10.1371/journal.pone.0052833

Figure 2. Notch signaling is downregulated in aortic medial VSMCs in DTAAD patients.

Figure 2

A) Immunofluorescence double staining showed that DLL1/4 in VSMCs of the aortic media was significantly decreased in both TAA and TAD tissues compared with control tissue. B) Notch1 in VSMCs of the aortic media was significantly decreased in both TAA and TAD tissues compared with control tissue (scale bar = 25 µm, insets 6.25 µm). C) NICD was rarely detected in vascular smooth muscle cells (VSMCs) of the aortic media in TAA and TAD tissues. D) Hes1 was rarely detected in VSMCs of the aortic media in TAA and TAD tissues (scale bar = 50 µm).