TABLE 1.

Incidence and scores of ear erythema in mice receiving intravenously lomefloxacin, tosufloxacin, and levofloxacin

Compound and dose (mg/kg)a	No. of animals with the indicated scoreb at:
	0 h				24 h				48 h				72 h				168 h
	0	1	2	3	0	1	2	3	0	1	2	3	0	1	2	3	0	1	2	3
Vehicle	6	0	0	0	6	0	0	0	6	0	0	0	6	0	0	0	6	0	0	0
Lomefloxacin
20	0	0	6	0	0	0	6	0	0	0	6	0	0	0	6	0	0	0	0	6
40	0	0	6	0	0	0	3	3	0	0	0	6	0	0	0	6	0	0	0	6
80	0	0	4	2	0	0	1	5	0	0	0	6	0	0	0	6	0	0	0	6
Tosufloxacin
20	0	1	5	0	3	3	0	0	5	1	0	0	6	0	0	0	6	0	0	0
40	0	0	6	0	2	4	0	0	4	2	0	0	5	1	0	0	6	0	0	0
80	0	0	6	0	0	1	5	0	0	5	1	0	4	1	1	0	5	1	0	0
Levofloxacin
20	6	0	0	0	6	0	0	0	6	0	0	0	6	0	0	0	6	0	0	0
40	5	1	0	0	6	0	0	0	6	0	0	0	6	0	0	0	6	0	0	0
80	2	4	0	0	6	0	0	0	6	0	0	0	6	0	0	0	6	0	0	0

^aSix mice were included in each dosing group.

^bThe scores for ear redness were as follows: 0, normal; 1, mild erythema; 2, moderate erythema; 3, severe erythema and edema.