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. 2012 Dec 26;7(12):e52362. doi: 10.1371/journal.pone.0052362

Figure 1. RenTg mice are hypertensive and develop chronic kidney disease progressively with the age.

Figure 1

Systolic blood pressure was highly increased in RenTg mice since the age of 3 months as compared to aged matched WT controls (A). Urinary excretion of albumin progressively increased with age to reach at 12 months highly elevated values in RenTg mice (B) whereas GFR significantly decreased (C). In accordance, the percentage of sclerotic glomeruli progressively increased in RenTg mice compared to WT mice (D). Representative examples of renal cortical slices after Masson’s Trichrome histology (E–I). Renal cortex of WT (E) as well as 3 month-old RenTg appeared normal (F); inflammatory lesions and renal fibrosis were evident at 5 (G), and 8 (H) months respectively in RenTg mice. Renal cortical tissue of 12 month old RenTg mice displayed several of the characteristics of hypertension-associated renal disease such as peri- vascular and glomerular inflammation, glomerulosclerosis, fibrinoid-like deposits within renal vessels, glomerular ischemia and tubular dilatation (I). Values are means ± SEM; n = 8 and 9 for wild type and RenTg mice, respectively for each time point; *P<0,05 or **P<0,01 vs WT. Magnification of the microphotographs: X200.