Table 2. Total CNV burden in each cohort for crystallized-type intelligence (gc).
All CNVs | Deletions | Duplications | |||||
Cohort | Sample size | Load | Rate | Load | Rate | Rate | Load |
ABC1936 | 412 | 12 | 0.029 | 2 | 0.005 | 10 | 0.024 |
LBC1921 | 492 | 24 | 0.049 | 8 | 0.016 | 16 | 0.033 |
LBC1936 | 887 | 47 | 0.053 | 15 | 0.017 | 32 | 0.036 |
Manchester | 723 | 44 | 0.061 | 12 | 0.017 | 32 | 0.044 |
Newcastle | 696 | 40 | 0.058 | 4 | 0.006 | 36 | 0.052 |
Total N | 3210 | 167 | 0.052 | 41 | 0.013 | 126 | 0.039 |
Total N represents the number of individuals with gc phenotypes, and high quality genetic data used to call CNVs. Load is the total number of CNVs counted in each cohort, called by both PennCNV and QuantiSNP, that passed quality control criteria, namely longer that 500 kb, and present at a frequency of 1% or less within each cohort, and Rate is the average number of such CNVs per individual within each cohort, with totals for All CNVs called, and separated into Deletions and Duplications.