Table 5. Total genes disrupted by CNVs in each cohort for fluid-type intelligence (gf).
All CNVs | Deletions | Duplications | |||||
Cohort | Sample Size | Gene Load | Rate | Gene Load | Rate | Gene Load | Rate |
ABC1936 | 346 | 37 | 0.107 | 8 | 0.023 | 29 | 0.084 |
LBC1921 | 482 | 60 | 0.125 | 10 | 0.021 | 50 | 0.104 |
LBC1936 | 877 | 144 | 0.164 | 56 | 0.064 | 88 | 0.100 |
Manchester | 730 | 81 | 0.111 | 19 | 0.026 | 62 | 0.085 |
Newcastle | 698 | 120 | 0.172 | 4 | 0.006 | 116 | 0.166 |
Total | 3133 | 442 | 0.141 | 97 | 0.031 | 345 | 0.110 |
Gene load is calculated as the number of genes whose co-ordinates +/−20 kb intersect with a CNV that passes QC checks (length ≥500 kb, and frequency ≤1%). Rate is the average number of such CNVs per individual.