TABLE 1.
Survival at day 16 by dose of fluconazole with or without flucytosine and without or with amphotericin B
Fluconazole dose (mg/kg/day) | % of mice alive at day 16 after treatment with flucytosine at (mg/kg/day):
|
||||||
---|---|---|---|---|---|---|---|
0 | 20 | 35 | 50 | 65 | 90 | 105 | |
Without amphotericin B | |||||||
0 | 0 | ||||||
10 | 50 | 25 | 0 | 50 | 0 | ||
16 | 75 | 75 | 100 | 100 | |||
24 | 100 | 75 | 100 | ||||
32 | 100 | 100 | 100 | 100 | |||
40 | 100 | 100 | 75 | 100 | 100 | ||
With amphotericin B | |||||||
0 | 70 | 75 | 75 | 100 | 100 | 100 | |
10 | 100 | 100 | 100 | 67 | 100 | ||
16 | 100 | 100 | 100 | 100 | |||
24 | 100 | 100 | 100 | ||||
32 | 100 | 100 | 100 | 100 | |||
40 | 100 | 100 | 75 | 100 | 100 |