Table 2. Mean (± SEM) plasma concentrations of cortisol, muscle protein levels of IR-β, IGF-1R, PKCζ and calpastatin, and muscle glycogen content in fetuses infused i.v. with either saline or cortisol for 5 days, and in fetuses whose mothers were injected i.m. with either saline or dexamethasone.
Fetal administration | Maternal administration | |||
Saline | Cortisol | Saline | Dexamethasone | |
Gestational age (days) | 130±0 | 131±0.2 | 127±0 | 127±0 |
Plasma cortisol (ng.ml−1) | 14.1±2.0 | 91.2±20.9* | 16.1±2.8 | 8.6±0.7* |
Muscle IR-β (au) | 1.00±0.20 | 1.11±0.10 | 1.00±0.06 | 0.88±0.06 |
Muscle IGF-1R (au) | 1.00±0.21 | 1.06±0.13 | 1.00±0.16 | 0.84±0.13 |
Muscle PKCζ (au) | 1.00±0.09 | 0.86±0.06 | 1.00±0.03 | 1.02±0.04 |
Muscle calpastatin (au) | 1.00±0.09 | 0.83±0.10 | 1.00±0.04 | 1.07±0.13 |
Muscle glycogen (mg.g tissue−1) | 46.27±3.72 | 48.38±2.21 | 48.70±1.95 | 50.51±3.14 |
, significantly different from the respective saline control group, Student’s t-test, p<0.05. IR-β, insulin receptor β-subunit; IGF-1R, insulin-like growth factor-1 receptor; PKCζ, protein kinase C ζ; au, arbitrary units.