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Parent drugs, their metabolites, and total antimalarial activity in plasma after oral administration to healthy volunteers. (a) Artemether (AM) at 5 mg/kg (n = 8); (b) artesunate (AS) at 100 mg (n = 6); (c) intravenous artesunate (IV AS) administered at a dose of 8 mg/kg to healthy rhesus monkeys (n = 10). Conc., concentration; DHA equiv., DHA concentration equivalents. Panels a and b are reprinted with permission (see references 34 and 35, respectively).
