. Author manuscript; available in PMC: 2014 Mar 25.

Published in final edited form as: Chem Biol Interact. 2012 Sep 7;203(1):77–80. doi: 10.1016/j.cbi.2012.08.019

Table 1.

Detailed kinetic analysis of tabun-hAChE conjugate reactivation by varying concentrations of oximes.^a

Oxime	k₊₂ / min⁻¹	K_OX / mM	k_r / M⁻¹min⁻¹	React_.max / %
RS194B	0.0018 ± 0.0002	1.8 ± 0.5	1.00 ± 0.29	70
RS150D	0.0015 ± 0.0001	0.41 ± 0.12	3.7 ± 1.2	70
RS41A	0.00082 ± 0.0001	3.6 ± 1.5	0.22 ± 0.10	40
2PAM	0.0058 ± 0.0006	1.5 ± 0.4	3.8 ± 1.1	70
DAM*	-	-	0.0042 ± 0.0003	<10
MINA*	-	-	0.039 ± 0.008	25

k₊₂ - the maximal first order reactivation rate constant, K_OX - the apparent phosphylated enzyme-oxime dissociation constant, k_r - the second-order rate constant of reactivation, React_.max - the maximal percentage of reactivation